mirror of
https://github.com/dnpm-dip/mv64e-mtb-dto-dotnet.git
synced 2025-07-01 18:32:54 +00:00
2607 lines
78 KiB
JSON
2607 lines
78 KiB
JSON
{
|
|
"patient": {
|
|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"gender": {
|
|
"code": "male",
|
|
"display": "Männlich",
|
|
"system": "Gender"
|
|
},
|
|
"birthDate": "1993-08-01",
|
|
"healthInsurance": {
|
|
"type": {
|
|
"code": "GKV",
|
|
"display": "gesetzliche Krankenversicherung",
|
|
"system": "http://fhir.de/CodeSystem/versicherungsart-de-basis"
|
|
},
|
|
"reference": {
|
|
"id": "1234567890",
|
|
"system": "https://www.dguv.de/arge-ik",
|
|
"display": "AOK",
|
|
"type": "HealthInsurance"
|
|
}
|
|
},
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|
"address": {
|
|
"municipalityCode": "12345"
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|
},
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|
"age": {
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|
"value": 31,
|
|
"unit": "Years"
|
|
},
|
|
"vitalStatus": {
|
|
"code": "alive",
|
|
"display": "Lebend",
|
|
"system": "dnpm-dip/patient/vital-status"
|
|
}
|
|
},
|
|
"episodesOfCare": [
|
|
{
|
|
"id": "dc4d1b2c-7468-4a4a-8fbd-1b0bb645c082",
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"patient": {
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
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"type": "Patient"
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|
},
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"period": {
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"start": "2024-11-30"
|
|
},
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|
"diagnoses": [
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|
{
|
|
"id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
|
|
"type": "MTBDiagnosis"
|
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}
|
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]
|
|
}
|
|
],
|
|
"diagnoses": [
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|
{
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|
"id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
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"patient": {
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
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"type": "Patient"
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},
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"recordedOn": "2022-09-01",
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"type": {
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|
"history": [
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{
|
|
"value": {
|
|
"code": "main",
|
|
"display": "Hauptdiagnose",
|
|
"system": "dnpm-dip/mtb/diagnosis/type"
|
|
},
|
|
"date": "2022-09-01"
|
|
}
|
|
]
|
|
},
|
|
"code": {
|
|
"code": "C57.0",
|
|
"display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
|
|
"system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm",
|
|
"version": "2025"
|
|
},
|
|
"topography": {
|
|
"code": "C57.0",
|
|
"display": "Eileiter",
|
|
"system": "urn:oid:2.16.840.1.113883.6.43.1",
|
|
"version": "Zweite Revision"
|
|
},
|
|
"grading": {
|
|
"history": [
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|
{
|
|
"date": "2022-09-01",
|
|
"codes": [
|
|
{
|
|
"code": "4",
|
|
"display": "4 = undifferenziert",
|
|
"system": "https://www.basisdatensatz.de/feld/161/grading"
|
|
},
|
|
{
|
|
"code": "1",
|
|
"display": "Pilocytic astrocytoma",
|
|
"system": "dnpm-dip/mtb/who-grading-cns-tumors",
|
|
"version": "2021"
|
|
}
|
|
]
|
|
}
|
|
]
|
|
},
|
|
"staging": {
|
|
"history": [
|
|
{
|
|
"date": "2022-09-01",
|
|
"method": {
|
|
"code": "clinical",
|
|
"display": "Klinisch",
|
|
"system": "dnpm-dip/mtb/tumor-staging/method"
|
|
},
|
|
"tnmClassification": {
|
|
"tumor": {
|
|
"code": "T1",
|
|
"system": "UICC"
|
|
},
|
|
"nodes": {
|
|
"code": "N3",
|
|
"system": "UICC"
|
|
},
|
|
"metastasis": {
|
|
"code": "M0",
|
|
"system": "UICC"
|
|
}
|
|
},
|
|
"otherClassifications": [
|
|
{
|
|
"code": "local",
|
|
"display": "Lokal",
|
|
"system": "dnpm-dip/mtb/diagnosis/kds-tumor-spread"
|
|
}
|
|
]
|
|
}
|
|
]
|
|
},
|
|
"guidelineTreatmentStatus": {
|
|
"code": "no-guidelines-available",
|
|
"display": "Keine Leitlinien vorhanden",
|
|
"system": "dnpm-dip/mtb/diagnosis/guideline-treatment-status"
|
|
},
|
|
"notes": [
|
|
"Notes on the tumor diagnosis..."
|
|
]
|
|
}
|
|
],
|
|
"guidelineTherapies": [
|
|
{
|
|
"id": "b63bcd3e-1bbb-425d-bd4f-03820036e249",
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|
"patient": {
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"reason": {
|
|
"id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
|
|
"display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
|
|
"type": "MTBDiagnosis"
|
|
},
|
|
"therapyLine": 8,
|
|
"intent": {
|
|
"code": "X",
|
|
"display": "Keine Angabe",
|
|
"system": "dnpm-dip/therapy/intent"
|
|
},
|
|
"category": {
|
|
"code": "S",
|
|
"display": "Sonstiges",
|
|
"system": "dnpm-dip/therapy/category"
|
|
},
|
|
"recordedOn": "2025-05-30",
|
|
"status": {
|
|
"code": "stopped",
|
|
"display": "Abgebrochen",
|
|
"system": "dnpm-dip/therapy/status"
|
|
},
|
|
"statusReason": {
|
|
"code": "progression",
|
|
"display": "Progression",
|
|
"system": "dnpm-dip/therapy/status-reason"
|
|
},
|
|
"period": {
|
|
"start": "2024-05-30",
|
|
"end": "2024-08-22"
|
|
},
|
|
"medication": [
|
|
{
|
|
"code": "L01XX57",
|
|
"display": "Plitidepsin",
|
|
"system": "http://fhir.de/CodeSystem/bfarm/atc",
|
|
"version": "2025"
|
|
}
|
|
],
|
|
"notes": [
|
|
"Notes on the therapy..."
|
|
]
|
|
},
|
|
{
|
|
"id": "d7de61c1-a5cc-429b-9c6f-e47765828f90",
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|
"patient": {
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"reason": {
|
|
"id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
|
|
"display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
|
|
"type": "MTBDiagnosis"
|
|
},
|
|
"therapyLine": 5,
|
|
"intent": {
|
|
"code": "P",
|
|
"display": "Palliativ",
|
|
"system": "dnpm-dip/therapy/intent"
|
|
},
|
|
"category": {
|
|
"code": "S",
|
|
"display": "Sonstiges",
|
|
"system": "dnpm-dip/therapy/category"
|
|
},
|
|
"recordedOn": "2025-05-30",
|
|
"status": {
|
|
"code": "stopped",
|
|
"display": "Abgebrochen",
|
|
"system": "dnpm-dip/therapy/status"
|
|
},
|
|
"statusReason": {
|
|
"code": "progression",
|
|
"display": "Progression",
|
|
"system": "dnpm-dip/therapy/status-reason"
|
|
},
|
|
"period": {
|
|
"start": "2024-02-29",
|
|
"end": "2024-10-03"
|
|
},
|
|
"medication": [
|
|
{
|
|
"code": "L01XX29",
|
|
"display": "Denileukindiftitox",
|
|
"system": "http://fhir.de/CodeSystem/bfarm/atc",
|
|
"version": "2025"
|
|
}
|
|
],
|
|
"notes": [
|
|
"Notes on the therapy..."
|
|
]
|
|
}
|
|
],
|
|
"guidelineProcedures": [
|
|
{
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|
"id": "960c989f-12f0-4592-96a8-fcb55938cd38",
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|
"patient": {
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"reason": {
|
|
"id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
|
|
"display": "Bösartige Neubildung: Tuba uterina [Falloppio]",
|
|
"type": "MTBDiagnosis"
|
|
},
|
|
"therapyLine": 3,
|
|
"intent": {
|
|
"code": "X",
|
|
"display": "Keine Angabe",
|
|
"system": "dnpm-dip/therapy/intent"
|
|
},
|
|
"code": {
|
|
"code": "surgery",
|
|
"display": "OP",
|
|
"system": "dnpm-dip/mtb/procedure/type"
|
|
},
|
|
"status": {
|
|
"code": "on-going",
|
|
"display": "Laufend",
|
|
"system": "dnpm-dip/therapy/status"
|
|
},
|
|
"statusReason": {
|
|
"code": "payment-pending",
|
|
"display": "Kostenübernahme noch ausstehend",
|
|
"system": "dnpm-dip/therapy/status-reason"
|
|
},
|
|
"recordedOn": "2025-05-30",
|
|
"period": {
|
|
"start": "2024-11-30"
|
|
},
|
|
"notes": [
|
|
"Notes on the therapeutic procedure..."
|
|
]
|
|
}
|
|
],
|
|
"performanceStatus": [
|
|
{
|
|
"id": "2d5108a3-600c-4153-8600-0427ad00d8a9",
|
|
"patient": {
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|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"effectiveDate": "2025-05-30",
|
|
"value": {
|
|
"code": "5",
|
|
"display": "ECOG 5",
|
|
"system": "ECOG-Performance-Status"
|
|
}
|
|
}
|
|
],
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|
"specimens": [
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|
{
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|
"id": "c59253e3-3c11-40bd-bc35-7c089f734862",
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|
"patient": {
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|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
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|
"type": "Patient"
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|
},
|
|
"diagnosis": {
|
|
"id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8",
|
|
"type": "MTBDiagnosis"
|
|
},
|
|
"type": {
|
|
"code": "unknown",
|
|
"display": "Unbekannt",
|
|
"system": "dnpm-dip/mtb/tumor-specimen/type"
|
|
},
|
|
"collection": {
|
|
"date": "2025-05-30",
|
|
"method": {
|
|
"code": "unknown",
|
|
"display": "Unbekannt",
|
|
"system": "dnpm-dip/mtb/tumor-specimen/collection/method"
|
|
},
|
|
"localization": {
|
|
"code": "primary-tumor",
|
|
"display": "Primärtumor",
|
|
"system": "dnpm-dip/mtb/tumor-specimen/collection/localization"
|
|
}
|
|
}
|
|
}
|
|
],
|
|
"priorDiagnosticReports": [
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|
{
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|
"id": "c02f0997-c43f-4da0-819e-d7ae7370d78d",
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|
"patient": {
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|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
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|
"type": "Patient"
|
|
},
|
|
"performer": {
|
|
"id": "xyz",
|
|
"display": "Molekular-Pathologie UKx",
|
|
"type": "Institute"
|
|
},
|
|
"issuedOn": "2025-05-30",
|
|
"specimen": {
|
|
"id": "c59253e3-3c11-40bd-bc35-7c089f734862",
|
|
"type": "TumorSpecimen"
|
|
},
|
|
"type": {
|
|
"code": "karyotyping",
|
|
"display": "Karyotyping",
|
|
"system": "dnpm-dip/mtb/molecular-diagnostics/type"
|
|
},
|
|
"results": [
|
|
"Result of diagnostics..."
|
|
]
|
|
}
|
|
],
|
|
"histologyReports": [
|
|
{
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|
"id": "791de8a5-b766-42d5-9454-12fbfe25ad92",
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|
"patient": {
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|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
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|
"type": "Patient"
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|
},
|
|
"specimen": {
|
|
"id": "c59253e3-3c11-40bd-bc35-7c089f734862",
|
|
"type": "TumorSpecimen"
|
|
},
|
|
"issuedOn": "2025-05-30",
|
|
"results": {
|
|
"tumorMorphology": {
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|
"id": "699db4c1-74a1-4c0f-bc20-275f85abfd20",
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|
"patient": {
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
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|
"type": "Patient"
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|
},
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|
"specimen": {
|
|
"id": "c59253e3-3c11-40bd-bc35-7c089f734862",
|
|
"type": "TumorSpecimen"
|
|
},
|
|
"value": {
|
|
"code": "8891/0",
|
|
"display": "Epitheloides Leiomyom",
|
|
"system": "urn:oid:2.16.840.1.113883.6.43.1",
|
|
"version": "Zweite Revision"
|
|
},
|
|
"note": "Notes..."
|
|
},
|
|
"tumorCellContent": {
|
|
"id": "5c408779-8f1c-4c44-a3f1-0bee32a0b7f1",
|
|
"patient": {
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|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"specimen": {
|
|
"id": "c59253e3-3c11-40bd-bc35-7c089f734862",
|
|
"type": "TumorSpecimen"
|
|
},
|
|
"method": {
|
|
"code": "histologic",
|
|
"display": "Histologisch",
|
|
"system": "dnpm-dip/mtb/tumor-cell-content/method"
|
|
},
|
|
"value": 0.022777185931090127
|
|
}
|
|
}
|
|
}
|
|
],
|
|
"ihcReports": [
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{
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|
"id": "d913c59b-7788-4931-a24c-5a71995ee77b",
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"patient": {
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
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|
"type": "Patient"
|
|
},
|
|
"specimen": {
|
|
"id": "c59253e3-3c11-40bd-bc35-7c089f734862",
|
|
"type": "TumorSpecimen"
|
|
},
|
|
"issuedOn": "2025-05-30",
|
|
"journalId": "7f39e2f3-6b0f-486d-b2d2-a1c8c4ec0493",
|
|
"blockIds": [
|
|
"a91d53a8-7949-4233-b710-1f1b456ff8c7"
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|
],
|
|
"results": {
|
|
"proteinExpression": [
|
|
{
|
|
"id": "60538b11-9da7-4248-a878-00dbfe31cf37",
|
|
"patient": {
|
|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"protein": {
|
|
"code": "HGNC:34",
|
|
"display": "ABCA4",
|
|
"system": "https://www.genenames.org/"
|
|
},
|
|
"value": {
|
|
"code": "2+",
|
|
"display": "2+",
|
|
"system": "dnpm-dip/mtb/ihc/protein-expression/result"
|
|
},
|
|
"tpsScore": 15,
|
|
"icScore": {
|
|
"code": "3",
|
|
"display": ">= 10%",
|
|
"system": "dnpm-dip/mtb/ihc/protein-expression/ic-score"
|
|
},
|
|
"tcScore": {
|
|
"code": "5",
|
|
"display": ">= 50%",
|
|
"system": "dnpm-dip/mtb/ihc/protein-expression/tc-score"
|
|
}
|
|
},
|
|
{
|
|
"id": "32a8c01c-4bd7-4ae9-8835-6ba747fe1991",
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|
"patient": {
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|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"protein": {
|
|
"code": "HGNC:886",
|
|
"display": "ATRX",
|
|
"system": "https://www.genenames.org/"
|
|
},
|
|
"value": {
|
|
"code": "not-exp",
|
|
"display": "Nicht exprimiert",
|
|
"system": "dnpm-dip/mtb/ihc/protein-expression/result"
|
|
},
|
|
"tpsScore": 33,
|
|
"icScore": {
|
|
"code": "2",
|
|
"display": ">= 5%",
|
|
"system": "dnpm-dip/mtb/ihc/protein-expression/ic-score"
|
|
},
|
|
"tcScore": {
|
|
"code": "5",
|
|
"display": ">= 50%",
|
|
"system": "dnpm-dip/mtb/ihc/protein-expression/tc-score"
|
|
}
|
|
},
|
|
{
|
|
"id": "edd1cb04-8c1a-49f7-bb88-36ee576ade21",
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|
"patient": {
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|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"protein": {
|
|
"code": "HGNC:886",
|
|
"display": "ATRX",
|
|
"system": "https://www.genenames.org/"
|
|
},
|
|
"value": {
|
|
"code": "3+",
|
|
"display": "3+",
|
|
"system": "dnpm-dip/mtb/ihc/protein-expression/result"
|
|
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"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"therapy": {
|
|
"id": "bc0b340d-17ea-4598-ad69-38d309e47182",
|
|
"type": "MTBSystemicTherapy"
|
|
},
|
|
"effectiveDate": "2025-02-07",
|
|
"method": {
|
|
"code": "RANO",
|
|
"display": "Nach RANO-Kriterien",
|
|
"system": "dnpm-dip/mtb/response/method"
|
|
},
|
|
"value": {
|
|
"code": "PR",
|
|
"display": "Partial Response",
|
|
"system": "RECIST"
|
|
}
|
|
},
|
|
{
|
|
"id": "89f6c606-0ec6-4b1e-a316-56a16eb52ea2",
|
|
"patient": {
|
|
"id": "e14bf9b6-7982-4933-a648-cfdea6484f1c",
|
|
"type": "Patient"
|
|
},
|
|
"therapy": {
|
|
"id": "e3d4b435-0531-4d75-827c-0da914f054dd",
|
|
"type": "MTBSystemicTherapy"
|
|
},
|
|
"effectiveDate": "2024-12-27",
|
|
"method": {
|
|
"code": "RECIST",
|
|
"display": "Nach RECIST-Kriterien",
|
|
"system": "dnpm-dip/mtb/response/method"
|
|
},
|
|
"value": {
|
|
"code": "SD",
|
|
"display": "Stable Disease",
|
|
"system": "RECIST"
|
|
}
|
|
}
|
|
]
|
|
}
|