diff --git a/mtb.go b/mtb.go index 13da8bb..6e0c8bf 100644 --- a/mtb.go +++ b/mtb.go @@ -23,6 +23,7 @@ type Mtb struct { Claims []Claim `json:"claims,omitempty"` Diagnoses []MtbDiagnosis `json:"diagnoses"` EpisodesOfCare []MtbEpisodeOfCare `json:"episodesOfCare"` + FamilyMemberHistories []FamilyMemberHistory `json:"familyMemberHistories,omitempty"` FollowUPS []FollowUp `json:"followUps,omitempty"` GuidelineProcedures []OncoProcedure `json:"guidelineProcedures,omitempty"` GuidelineTherapies []MtbSystemicTherapy `json:"guidelineTherapies,omitempty"` @@ -343,6 +344,19 @@ type PeriodDate struct { Start string `json:"start"` } +type FamilyMemberHistory struct { + ID string `json:"id"` + Patient Reference `json:"patient"` + Relationship FamilyMemberHistoryRelationshipTypeCoding `json:"relationship"` +} + +type FamilyMemberHistoryRelationshipTypeCoding struct { + Code FamilyMemberHistoryRelationshipTypeCodingCode `json:"code"` + Display *string `json:"display,omitempty"` + System *string `json:"system,omitempty"` + Version *string `json:"version,omitempty"` +} + type FollowUp struct { Date string `json:"date"` LastContactDate *string `json:"lastContactDate,omitempty"` @@ -1095,6 +1109,13 @@ const ( Secondary ValueCode = "secondary" ) +type FamilyMemberHistoryRelationshipTypeCodingCode string + +const ( + EXT FamilyMemberHistoryRelationshipTypeCodingCode = "EXT" + Fammemb FamilyMemberHistoryRelationshipTypeCodingCode = "FAMMEMB" +) + type FollowUpPatientStatusCodingCode string const ( diff --git a/tests/mv64e-mtb-fake-patient.json b/tests/mv64e-mtb-fake-patient.json index c9fb5b2..291f22d 100644 --- a/tests/mv64e-mtb-fake-patient.json +++ b/tests/mv64e-mtb-fake-patient.json @@ -1,13 +1,12 @@ { "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "gender": { - "code": "female", - "display": "Weiblich", + "code": "male", + "display": "Männlich", "system": "Gender" }, - "birthDate": "1994-01-04", - "dateOfDeath": "2010-01-04", + "birthDate": "1961-09-01", "healthInsurance": { "type": { "code": "GKV", @@ -25,28 +24,28 @@ "municipalityCode": "12345" }, "age": { - "value": 16, + "value": 63, "unit": "Years" }, "vitalStatus": { - "code": "deceased", - "display": "Verstorben", + "code": "alive", + "display": "Lebend", "system": "dnpm-dip/patient/vital-status" } }, "episodesOfCare": [ { - "id": "4bdf2967-2e9f-4fac-9210-764918dc9e7e", + "id": "5481850f-f266-4d2f-8fbc-6bb790680d8f", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "period": { - "start": "2024-12-18" + "start": "2024-12-24" }, "diagnoses": [ { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", "type": "MTBDiagnosis" } ] @@ -54,12 +53,12 @@ ], "diagnoses": [ { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, - "recordedOn": "2006-05-04", + "recordedOn": "2023-03-01", "type": { "history": [ { @@ -68,35 +67,35 @@ "display": "Hauptdiagnose", "system": "dnpm-dip/mtb/diagnosis/type" }, - "date": "2006-05-04" + "date": "2023-03-01" } ] }, "code": { - "code": "C54.0", - "display": "Bösartige Neubildung: Isthmus uteri", + "code": "C50.1", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm", "version": "2025" }, "topography": { - "code": "C54.0", - "display": "Isthmus uteri", + "code": "C50.1", + "display": "Zentraler Drüsenkörper der Brust", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "grading": { "history": [ { - "date": "2006-05-04", + "date": "2023-03-01", "codes": [ { - "code": "H", - "display": "H = high grade (G3 oder G4)", + "code": "U", + "display": "U = unbekannt", "system": "https://www.basisdatensatz.de/feld/161/grading" }, { - "code": "3", - "display": "Anaplastic astrocytoma", + "code": "2", + "display": "Diffuse astrocytoma", "system": "dnpm-dip/mtb/who-grading-cns-tumors", "version": "2021" } @@ -107,7 +106,7 @@ "staging": { "history": [ { - "date": "2006-05-04", + "date": "2023-03-01", "method": { "code": "clinical", "display": "Klinisch", @@ -115,22 +114,22 @@ }, "tnmClassification": { "tumor": { - "code": "Tx", + "code": "T1", "system": "UICC" }, "nodes": { - "code": "N0", + "code": "N2", "system": "UICC" }, "metastasis": { - "code": "M0", + "code": "Mx", "system": "UICC" } }, "otherClassifications": [ { - "code": "metastasized", - "display": "Metastasiert", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/diagnosis/kds-tumor-spread" } ] @@ -138,8 +137,8 @@ ] }, "guidelineTreatmentStatus": { - "code": "non-exhausted", - "display": "Leitlinien nicht ausgeschöpft", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/diagnosis/guideline-treatment-status" }, "notes": [ @@ -147,30 +146,44 @@ ] } ], + "familyMemberHistories": [ + { + "id": "f982b161-f8a3-4b5b-a390-1ef0d84efc1b", + "patient": { + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "type": "Patient" + }, + "relationship": { + "code": "EXT", + "display": "Verwandter weiteren Grades", + "system": "dnpm-dip/mtb/family-meber-history/relationship-type" + } + } + ], "guidelineTherapies": [ { - "id": "63d3a2df-c1c7-40b6-9b4c-796b7f67e098", + "id": "0c696b1a-d123-419b-9a6f-e79322392f4e", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", "type": "MTBDiagnosis" }, - "therapyLine": 2, + "therapyLine": 3, "intent": { - "code": "P", - "display": "Palliativ", + "code": "X", + "display": "Keine Angabe", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "N", - "display": "Neoadjuvant", + "code": "I", + "display": "Intraopterativ", "system": "dnpm-dip/therapy/category" }, - "recordedOn": "2025-06-18", + "recordedOn": "2025-06-24", "status": { "code": "stopped", "display": "Abgebrochen", @@ -182,13 +195,13 @@ "system": "dnpm-dip/therapy/status-reason" }, "period": { - "start": "2023-10-18", - "end": "2024-06-19" + "start": "2024-04-24", + "end": "2024-12-18" }, "medication": [ { - "code": "L01EX28", - "display": "Repotrectinib", + "code": "L01EX02", + "display": "Sorafenib", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -198,28 +211,28 @@ ] }, { - "id": "c8b0432c-f190-4dfe-a22a-0d00969ccdce", + "id": "da26f4c4-834e-4f6a-86eb-4df13c4a442f", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", "type": "MTBDiagnosis" }, - "therapyLine": 2, + "therapyLine": 4, "intent": { - "code": "S", - "display": "Sonstiges", + "code": "X", + "display": "Keine Angabe", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "N", - "display": "Neoadjuvant", + "code": "A", + "display": "Adjuvant", "system": "dnpm-dip/therapy/category" }, - "recordedOn": "2025-06-18", + "recordedOn": "2025-06-24", "status": { "code": "stopped", "display": "Abgebrochen", @@ -231,13 +244,13 @@ "system": "dnpm-dip/therapy/status-reason" }, "period": { - "start": "2023-10-18", - "end": "2024-05-01" + "start": "2024-06-24", + "end": "2025-02-24" }, "medication": [ { - "code": "L01XX86", - "display": "Calaspargase pegol", + "code": "L01EX13", + "display": "Gilteritinib", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -249,20 +262,60 @@ ], "guidelineProcedures": [ { - "id": "380e2338-5cab-45f3-83f1-7e655b560c7c", + "id": "09ac6bfb-05bb-4c8f-b65a-dae96407939c", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", "type": "MTBDiagnosis" }, "therapyLine": 3, "intent": { - "code": "K", - "display": "Kurativ", + "code": "X", + "display": "Keine Angabe", + "system": "dnpm-dip/therapy/intent" + }, + "code": { + "code": "nuclear-medicine", + "display": "Nuklearmedizinische Therapie", + "system": "dnpm-dip/mtb/procedure/type" + }, + "status": { + "code": "stopped", + "display": "Abgebrochen", + "system": "dnpm-dip/therapy/status" + }, + "statusReason": { + "code": "patient-death", + "display": "Tod", + "system": "dnpm-dip/therapy/status-reason" + }, + "recordedOn": "2025-06-24", + "period": { + "start": "2024-12-24" + }, + "notes": [ + "Notes on the therapeutic procedure..." + ] + }, + { + "id": "1d12955f-216f-4731-8a37-e2eca4c2a735", + "patient": { + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "type": "Patient" + }, + "reason": { + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "type": "MTBDiagnosis" + }, + "therapyLine": 1, + "intent": { + "code": "S", + "display": "Sonstiges", "system": "dnpm-dip/therapy/intent" }, "code": { @@ -276,53 +329,13 @@ "system": "dnpm-dip/therapy/status" }, "statusReason": { - "code": "chronic-remission", - "display": "Anhaltende Remission", + "code": "progression", + "display": "Progression", "system": "dnpm-dip/therapy/status-reason" }, - "recordedOn": "2025-06-18", + "recordedOn": "2025-06-24", "period": { - "start": "2024-12-18" - }, - "notes": [ - "Notes on the therapeutic procedure..." - ] - }, - { - "id": "52a639e2-a857-4d36-b115-9537542207f8", - "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", - "type": "MTBDiagnosis" - }, - "therapyLine": 5, - "intent": { - "code": "P", - "display": "Palliativ", - "system": "dnpm-dip/therapy/intent" - }, - "code": { - "code": "surgery", - "display": "OP", - "system": "dnpm-dip/mtb/procedure/type" - }, - "status": { - "code": "stopped", - "display": "Abgebrochen", - "system": "dnpm-dip/therapy/status" - }, - "statusReason": { - "code": "patient-refusal", - "display": "Therapie durch Patient abgelehnt", - "system": "dnpm-dip/therapy/status-reason" - }, - "recordedOn": "2025-06-18", - "period": { - "start": "2024-12-18" + "start": "2024-12-24" }, "notes": [ "Notes on the therapeutic procedure..." @@ -331,45 +344,45 @@ ], "performanceStatus": [ { - "id": "fa501ef1-8861-495c-b267-0ebf25eab69d", + "id": "7cf3d19b-a537-47e4-b7f0-d324e8b1ad70", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, - "effectiveDate": "2025-06-18", + "effectiveDate": "2025-06-24", "value": { - "code": "5", - "display": "ECOG 5", + "code": "1", + "display": "ECOG 1", "system": "ECOG-Performance-Status" } } ], "specimens": [ { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "diagnosis": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", "type": "MTBDiagnosis" }, "type": { - "code": "fresh-tissue", - "display": "Frischgewebe", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/tumor-specimen/type" }, "collection": { - "date": "2025-06-18", + "date": "2025-06-24", "method": { - "code": "biopsy", - "display": "Biopsie", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/tumor-specimen/collection/method" }, "localization": { - "code": "local-recurrence", - "display": "Lokalrezidiv", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/tumor-specimen/collection/localization" } } @@ -377,9 +390,9 @@ ], "priorDiagnosticReports": [ { - "id": "c628b8ee-cb29-48e7-961f-2808ca4005ed", + "id": "0209a1fa-3948-4bc5-a2f5-988818057544", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "performer": { @@ -387,14 +400,14 @@ "display": "Molekular-Pathologie UKx", "type": "Institute" }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, "type": { - "code": "gene-panel", - "display": "Genpanel", + "code": "fusion-panel", + "display": "Fusionspanel", "system": "dnpm-dip/mtb/molecular-diagnostics/type" }, "results": [ @@ -404,43 +417,43 @@ ], "histologyReports": [ { - "id": "818d2577-989b-46dc-bd9a-4d5416b4dd11", + "id": "1c51bb6f-b551-43a4-9923-6db7fe36440c", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", "results": { "tumorMorphology": { - "id": "fd271a56-9287-40a2-ac18-f33874c91170", + "id": "a177e88e-af76-45c8-ba93-e2f2339888a0", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, "value": { - "code": "9725/1", - "display": "Hydroa-vacciniform-lymphoproliferative Erkrankung", + "code": "9719/3", + "display": "Nasales NK/T-Zell-Lymphom", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "note": "Notes..." }, "tumorCellContent": { - "id": "856a7ed6-fc28-4beb-a0bf-c96895c1c2bb", + "id": "32605a2f-4c5c-4f5a-9909-326955405fe0", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, "method": { @@ -448,118 +461,34 @@ "display": "Histologisch", "system": "dnpm-dip/mtb/tumor-cell-content/method" }, - "value": 0.7691964184191502 + "value": 0.40875903241796807 } } } ], "ihcReports": [ { - "id": "cfded8da-7ca9-4e54-adfc-e3a723a2aaec", + "id": "ced8a836-262e-4067-b272-94c8f9222446", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", "results": { "proteinExpression": [ { - "id": "71b2cbc9-c250-4fdf-95f8-11ef68c7119c", + "id": "07bdd4f4-6df7-4c22-9ef2-2abb86cf4666", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "protein": { - "code": "HGNC:3236", - "display": "EGFR", - "system": "https://www.genenames.org/" - }, - "value": { - "code": "3+", - "display": "3+", - "system": "dnpm-dip/mtb/ihc/protein-expression/result" - }, - "tpsScore": 45, - "icScore": { - "code": "3", - "display": ">= 10%", - "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" - }, - "tcScore": { - "code": "4", - "display": ">= 25%", - "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" - } - }, - { - "id": "6137eab8-f33b-4f98-a9b3-78589815cb1b", - "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "protein": { - "code": "HGNC:76", - "display": "ABL1", - "system": "https://www.genenames.org/" - }, - "value": { - "code": "unknown", - "display": "untersucht, kein Ergebnis", - "system": "dnpm-dip/mtb/ihc/protein-expression/result" - }, - "tpsScore": 82, - "icScore": { - "code": "1", - "display": ">= 1%", - "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" - }, - "tcScore": { - "code": "4", - "display": ">= 25%", - "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" - } - }, - { - "id": "13725397-cb4a-4c66-a616-925c692e7a5b", - "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "protein": { - "code": "HGNC:391", - "display": "AKT1", - "system": "https://www.genenames.org/" - }, - "value": { - "code": "unknown", - "display": "untersucht, kein Ergebnis", - "system": "dnpm-dip/mtb/ihc/protein-expression/result" - }, - "tpsScore": 10, - "icScore": { - "code": "2", - "display": ">= 5%", - "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" - }, - "tcScore": { - "code": "1", - "display": ">= 1%", - "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" - } - }, - { - "id": "3eeb2b9d-d482-4e53-bc74-facb50bd9ea3", - "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "protein": { - "code": "HGNC:21298", - "display": "AACS", + "code": "HGNC:3942", + "display": "MTOR", "system": "https://www.genenames.org/" }, "value": { @@ -567,50 +496,106 @@ "display": "Nicht exprimiert", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 10, + "tpsScore": 21, "icScore": { "code": "1", "display": ">= 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "1", - "display": ">= 1%", + "code": "6", + "display": ">= 75%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } }, { - "id": "800d7a08-147b-45aa-9909-1ce5fea971e7", + "id": "38ac3c86-7d13-4d5d-a85d-7d79846aa85d", "patient": { - 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"code": "not-exp", - "display": "Nicht exprimiert", + "code": "unknown", + "display": "untersucht, kein Ergebnis", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 44, + "tpsScore": 51, "icScore": { - "code": "1", - "display": ">= 1%", + "code": "2", + "display": ">= 5%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { - "code": "0", - "display": "< 1%", + "code": "3", + "display": ">= 10%", "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" } }, { - "id": "2ca95d9c-cffb-4268-a448-e9df5bc1e065", + "id": "cf0ff1b1-e0db-48f3-aa07-684d626f939f", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "protein": { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, "value": { - "code": "exp", - "display": "Exprimiert", + "code": "not-exp", + "display": "Nicht exprimiert", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - 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"id": "569537ab-93ee-436b-9ed3-e9c04e8e3641", + "id": "26a6f41e-c2a4-4a28-ba62-95453c880579", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, "method": { @@ -710,36 +695,36 @@ "display": "Bioinformatisch", "system": "dnpm-dip/mtb/tumor-cell-content/method" }, - "value": 0.4518313013298274 + "value": 0.9426267499137174 }, "tmb": { - "id": "4e1bb8d3-7451-4b4f-9f5d-bad57f2b7fb2", + "id": "7357476b-fb64-452f-9f47-28babfc7941a", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, "value": { - "value": 10123, + "value": 98248, "unit": "Mutations per megabase" }, "interpretation": { - 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"code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:1777", + "display": "CDK6", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3236", - "display": "EGFR", - "system": "https://www.genenames.org/" - } - ] - }, - { - "id": "d4352f6d-2bf2-47cc-8b40-2588bd7cfc2e", - "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "chromosome": "chr20", - "localization": [ - { - "code": "regulatory-region", - "display": "Regulatory region", - "system": "dnpm-dip/variant/localization" - } - ], - "startRange": { - "start": 25177, - "end": 25219 - }, - "endRange": { - "start": 25798, - "end": 25848 - }, - "totalCopyNumber": 6, - "relativeCopyNumber": 0.4089412068181695, - "cnA": 0.9024490217750547, - "cnB": 0.8810785629496372, - "reportedAffectedGenes": [ - { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, { - "code": "HGNC:25829", - "display": "ABRAXAS1", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:25662", - "display": "AAGAB", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:34", - "display": "ABCA4", + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" }, { @@ -1524,11 +1352,6 @@ "display": "EGFR", "system": "https://www.genenames.org/" }, - { - "code": "HGNC:21597", - "display": "ACAD10", - "system": "https://www.genenames.org/" - }, { "code": "HGNC:18615", "display": "BRAFP1", @@ -1553,8 +1376,18 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:391", + "display": "AKT1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" }, { @@ -1563,89 +1396,44 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:1777", - "display": "CDK6", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:21298", - "display": "AACS", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:25662", - "display": "AAGAB", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:1100", - "display": "BRCA1", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:18615", - "display": "BRAFP1", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" } ] }, { - "id": "dc9a372f-2318-43a7-8ce4-cb0d79f15ba1", + "id": "79b1b2f1-eece-469a-bf9d-d742ace3b4f5", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, - "chromosome": "chrX", + "chromosome": "chr4", "localization": [ { - "code": "intergenic", - "display": "Intergenic", + "code": "splicing-region", + "display": "splicing region", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 45191, - "end": 45233 + "start": 10032, + "end": 10074 }, "endRange": { - "start": 45420, - "end": 45470 + "start": 10429, + "end": 10479 }, - "totalCopyNumber": 1, - "relativeCopyNumber": 0.0068665843381129354, - "cnA": 0.9045882598400938, - "cnB": 0.6829665691976955, + "totalCopyNumber": 2, + "relativeCopyNumber": 0.43102997556480316, + "cnA": 0.0626602855041446, + "cnB": 0.9272306017862723, "reportedAffectedGenes": [ - { - "code": "HGNC:11998", - "display": "TP53", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:5173", - "display": "HRAS", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:6973", - "display": "MDM2", - "system": "https://www.genenames.org/" - }, { "code": "HGNC:3690", "display": "FGFR3", "system": "https://www.genenames.org/" }, - { - "code": "HGNC:25662", - "display": "AAGAB", - "system": "https://www.genenames.org/" - }, { "code": "HGNC:76", "display": "ABL1", @@ -1660,33 +1448,33 @@ "code": "HGNC:6407", "display": "KRAS", "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:25662", + "display": "AAGAB", + "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", "type": { - "code": "loss", - "display": "Loss", + "code": "low-level-gain", + "display": "Low-level-gain", "system": "dnpm-dip/mtb/ngs-report/cnv/type" }, "copyNumberNeutralLoH": [ { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, { - "code": "HGNC:6973", - "display": "MDM2", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3690", - "display": "FGFR3", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:25829", + "display": "ABRAXAS1", "system": "https://www.genenames.org/" }, { @@ -1695,8 +1483,8 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:1777", + "display": "CDK6", "system": "https://www.genenames.org/" }, { @@ -1704,6 +1492,118 @@ "display": "ABCA4", "system": "https://www.genenames.org/" }, + { + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + } + ] + }, + { + "id": "7ef061c2-25d3-4ab1-b3b5-415711e74763", + "patient": { + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "type": "Patient" + }, + "chromosome": "chr1", + "localization": [ + { + "code": "intronic", + "display": "Intronic", + "system": "dnpm-dip/variant/localization" + } + ], + "startRange": { + "start": 21367, + "end": 21409 + }, + "endRange": { + "start": 22243, + "end": 22293 + }, + "totalCopyNumber": 6, + "relativeCopyNumber": 0.5325580143964234, + "cnA": 0.001090613467988999, + "cnB": 0.796867620835479, + "reportedAffectedGenes": [ + { + "code": "HGNC:11998", + "display": "TP53", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:25829", + "display": "ABRAXAS1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:76", + "display": "ABL1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6407", + "display": "KRAS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3942", + "display": "MTOR", + "system": "https://www.genenames.org/" + } + ], + "reportedFocality": "partial q-arm", + "type": { + "code": "high-level-gain", + "display": "High-level-gain", + "system": "dnpm-dip/mtb/ngs-report/cnv/type" + }, + "copyNumberNeutralLoH": [ + { + "code": "HGNC:25829", + "display": "ABRAXAS1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6973", + "display": "MDM2", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:25662", + "display": "AAGAB", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:76", + "display": "ABL1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:886", + "display": "ATRX", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3689", + "display": "FGFR2", + "system": "https://www.genenames.org/" + }, { "code": "HGNC:3942", "display": "MTOR", @@ -1717,35 +1617,35 @@ ] }, { - "id": "a419c301-0da5-49f8-a691-93760fe18494", + "id": "b6c87ffe-cafa-4017-8304-cc7d5e5ed6ef", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, - "chromosome": "chr17", + "chromosome": "chr4", "localization": [ { - "code": "intronic", - "display": "Intronic", + "code": "intergenic", + "display": "Intergenic", "system": "dnpm-dip/variant/localization" } ], "startRange": { - "start": 42151, - "end": 42193 + "start": 28913, + "end": 28955 }, "endRange": { - "start": 43039, - "end": 43089 + "start": 29073, + "end": 29123 }, - "totalCopyNumber": 1, - "relativeCopyNumber": 0.9392018237630932, - "cnA": 0.49943029992502197, - "cnB": 0.3061034066662738, + "totalCopyNumber": 5, + "relativeCopyNumber": 0.24079048197395347, + "cnA": 0.8864208860638342, + "cnB": 0.9335254612742215, "reportedAffectedGenes": [ { - "code": "HGNC:5173", - "display": "HRAS", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, { @@ -1754,13 +1654,8 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:6973", - "display": "MDM2", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" }, { @@ -1768,57 +1663,24 @@ "display": "CDK6", "system": "https://www.genenames.org/" }, + { + "code": "HGNC:9967", + "display": "RET", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3689", + "display": "FGFR2", + "system": "https://www.genenames.org/" + }, { "code": "HGNC:34", "display": "ABCA4", "system": "https://www.genenames.org/" }, { - "code": "HGNC:9967", - "display": "RET", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:21298", - "display": "AACS", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:3689", - "display": "FGFR2", - "system": "https://www.genenames.org/" - } - ], - "reportedFocality": "partial q-arm", - "type": { - "code": "loss", - "display": "Loss", - "system": "dnpm-dip/mtb/ngs-report/cnv/type" - }, - "copyNumberNeutralLoH": [ - { - "code": "HGNC:33", - "display": "ABCA3", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:25662", - "display": "AAGAB", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:1777", - "display": "CDK6", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:9967", - "display": "RET", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:21298", - "display": "AACS", + "code": "HGNC:3942", + "display": "MTOR", "system": "https://www.genenames.org/" }, { @@ -1831,80 +1693,62 @@ "display": "KRAS", "system": "https://www.genenames.org/" } + ], + "reportedFocality": "partial q-arm", + "type": { + "code": "high-level-gain", + "display": "High-level-gain", + "system": "dnpm-dip/mtb/ngs-report/cnv/type" + }, + "copyNumberNeutralLoH": [ + { + "code": "HGNC:33", + "display": "ABCA3", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:11998", + "display": "TP53", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:25829", + "display": "ABRAXAS1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:34", + "display": "ABCA4", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1097", + "display": "BRAF", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:1100", + "display": "BRCA1", + "system": "https://www.genenames.org/" + } ] } ], "dnaFusions": [ { - "id": "0cbe5df0-8c5e-4352-ae80-58b18bc99e03", + "id": "80439a87-61a6-449f-ab0e-ea207336b650", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "localization": [ - { - "code": "regulatory-region", - "display": "Regulatory region", - "system": "dnpm-dip/variant/localization" - } - ], - "fusionPartner5prime": { - "chromosome": "chr12", - "gene": { - "code": "HGNC:886", - "display": "ATRX", - "system": "https://www.genenames.org/" - }, - "position": 694 - }, - "fusionPartner3prime": { - "chromosome": "chr4", - "gene": { - "code": "HGNC:1097", - "display": "BRAF", - "system": "https://www.genenames.org/" - }, - "position": 125 - }, - "reportedNumReads": 6 - }, - { - "id": "a17f336a-0ea4-4bb7-8e46-8fd3ea8c400e", - "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "localization": [ - { - "code": "intergenic", - "display": "Intergenic", - "system": "dnpm-dip/variant/localization" - } - ], - "fusionPartner5prime": { - 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"id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", "reason": { - "code": "family-anamnesis", - "display": "Familienanamnese", + "code": "self-anamnesis", + "display": "Eigenanamnese", "system": "dnpm-dip/mtb/recommendation/genetic-counseling/reason" } }, "medicationRecommendations": [ { - "id": "6a91f8db-8cde-4be1-84c6-f0c4fd4a2105", + "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-18", - "priority": { - "code": "1", - "display": "1", - "system": "dnpm-dip/recommendation/priority" - }, - "levelOfEvidence": { - "grading": { - "code": "undefined", - "display": "Nicht definiert", - "system": "dnpm-dip/mtb/level-of-evidence/grading" - }, - "addendums": [ - { - "code": "iv", - "display": "iv", - "system": "dnpm-dip/mtb/level-of-evidence/addendum" - } - ], - "publications": [ - { - "id": "1570997794", - "system": "https://pubmed.ncbi.nlm.nih.gov", - "type": "Publication" - } - ] - }, - "category": { - "code": "SZ", - "display": "Stammzelltransplantation (inklusive Knochenmarktransplantation)", - "system": "dnpm-dip/mtb/recommendation/systemic-therapy/category" - }, - "medication": [ - { - "code": "L01XX79", - "display": "Eflornithin", - "system": "http://fhir.de/CodeSystem/bfarm/atc", - "version": "2025" - } - ], - "useType": { - "code": "compassionate", - "display": "Compassionate Use", - "system": "dnpm-dip/mtb/recommendation/systemic-therapy/use-type" - }, - "supportingVariants": [ - { - "variant": { - "id": "0cbe5df0-8c5e-4352-ae80-58b18bc99e03", - "type": "Variant" - }, - "gene": { - "code": "HGNC:886", - "display": "ATRX", - "system": "https://www.genenames.org/" - } - } - ] - } - ], - "procedureRecommendations": [ - { - "id": "64a53b73-9152-4a8c-8685-f10be92be4c0", - "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", - "type": "Patient" - }, - "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", - "type": "MTBDiagnosis" - }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", "priority": { "code": "4", "display": "4", @@ -2541,8 +2280,8 @@ }, "levelOfEvidence": { "grading": { - "code": "m1A", - "display": "m1A", + "code": "m2B", + "display": "m2B", "system": "dnpm-dip/mtb/level-of-evidence/grading" }, "addendums": [ @@ -2554,45 +2293,63 @@ ], "publications": [ { - "id": "224732002", + "id": "1802087682", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } ] }, - "code": { + "category": { "code": "SO", "display": "Sonstiges", - "system": "dnpm-dip/mtb/recommendation/procedure/category" + "system": "dnpm-dip/mtb/recommendation/systemic-therapy/category" + }, + "medication": [ + { + "code": "L01XX77", + "display": "Adagrasib", + "system": "http://fhir.de/CodeSystem/bfarm/atc", + "version": "2025" + } + ], + "useType": { + "code": "sec-preventive", + "display": "Sec-preventive", + "system": "dnpm-dip/mtb/recommendation/systemic-therapy/use-type" }, "supportingVariants": [ { "variant": { - "id": "a17f336a-0ea4-4bb7-8e46-8fd3ea8c400e", + "id": "a9487572-a2a5-4074-ba8b-1e73cf92b378", "type": "Variant" }, "gene": { - "code": "HGNC:1753", - "display": "CDH13", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" } } ] } ], - "studyEnrollmentRecommendations": [ + "procedureRecommendations": [ { - "id": "9e830774-b888-4cb2-8883-29bb6513c4a9", + "id": "1f5aebc0-2f32-4fdf-96e3-ba2309a580e3", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", + "priority": { + "code": "2", + "display": "2", + "system": "dnpm-dip/recommendation/priority" + }, "levelOfEvidence": { "grading": { "code": "undefined", @@ -2601,35 +2358,28 @@ }, "addendums": [ { - "code": "iv", - "display": "iv", + "code": "R", + "display": "R", "system": "dnpm-dip/mtb/level-of-evidence/addendum" } ], "publications": [ { - "id": "1570997794", + "id": "519591396", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } ] }, - "priority": { - "code": "3", - "display": "3", - "system": "dnpm-dip/recommendation/priority" + "code": { + "code": "AS", + "display": "Active Surveillance", + "system": "dnpm-dip/mtb/recommendation/procedure/category" }, - "study": [ - { - "id": "DRKS00003728", - "system": "DRKS", - "type": "Study" - } - ], "supportingVariants": [ { "variant": { - "id": "0cbe5df0-8c5e-4352-ae80-58b18bc99e03", + "id": "828dfee4-37e4-485a-8c6f-49f863903f3f", "type": "Variant" }, "gene": { @@ -2641,32 +2391,93 @@ ] } ], + "studyEnrollmentRecommendations": [ + { + "id": "590cd85f-24b9-435c-bb63-8a719dfa7c8e", + "patient": { + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", + "type": "Patient" + }, + "reason": { + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", + "type": "MTBDiagnosis" + }, + "issuedOn": "2025-06-24", + "levelOfEvidence": { + "grading": { + "code": "m2B", + "display": "m2B", + "system": "dnpm-dip/mtb/level-of-evidence/grading" + }, + "addendums": [ + { + "code": "R", + "display": "R", + "system": "dnpm-dip/mtb/level-of-evidence/addendum" + } + ], + "publications": [ + { + "id": "1802087682", + "system": "https://pubmed.ncbi.nlm.nih.gov", + "type": "Publication" + } + ] + }, + "priority": { + "code": "1", + "display": "1", + "system": "dnpm-dip/recommendation/priority" + }, + "study": [ + { + "id": "0509-104679-07-52", + "system": "Eudra-CT", + "type": "Study" + } + ], + "supportingVariants": [ + { + "variant": { + "id": "a9487572-a2a5-4074-ba8b-1e73cf92b378", + "type": "Variant" + }, + "gene": { + "code": "HGNC:11998", + "display": "TP53", + "system": "https://www.genenames.org/" + } + } + ] + } + ], "histologyReevaluationRequests": [ { - "id": "4409db9f-6560-41e8-a7fd-4a5a398d917e", + "id": "38f2133a-f1cf-4af6-b441-c21953e43ed3", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "specimen": { - "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", + "id": "c3f30fe7-d193-4cde-a3c2-ef8f2497df51", "type": "TumorSpecimen" }, - "issuedOn": "2025-06-18" + "issuedOn": "2025-06-24" } ], "rebiopsyRequests": [ { - "id": "692b1fec-1ed2-4c70-a6d1-d1d1fdec160b", + "id": "0860944d-ede1-453b-b7ea-b13ea0fb1d2f", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "tumorEntity": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", "type": "MTBDiagnosis" }, - "issuedOn": "2025-06-18" + "issuedOn": "2025-06-24" } ], "notes": [ @@ -2676,45 +2487,45 @@ ], "followUps": [ { - "date": "2009-10-19", + "date": "2025-06-03", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, - "lastContactDate": "2009-10-19" + "lastContactDate": "2025-06-03" } ], "claims": [ { - "id": "5f9a50b7-582f-404f-b50c-92077e19daba", + "id": "5ec237d4-4857-475a-9931-0aa374a93634", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "recommendation": { - "id": "6a91f8db-8cde-4be1-84c6-f0c4fd4a2105", + "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9", "type": "MTBMedicationRecommendation" }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", "stage": { - "code": "initial-claim", - "display": "Erstantrag", + "code": "unknown", + "display": "Unbekannt", "system": "dnpm-dip/mtb/claim/stage" } } ], "claimResponses": [ { - "id": "be291eca-2333-41e1-bcd2-e845212049ba", + "id": "fed8817e-708a-4230-a7e1-95594b67e5ce", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "claim": { - "id": "5f9a50b7-582f-404f-b50c-92077e19daba", + "id": "5ec237d4-4857-475a-9931-0aa374a93634", "type": "Claim" }, - "issuedOn": "2025-06-18", + "issuedOn": "2025-06-24", "status": { "code": "accepted", "display": "Angenommen", @@ -2726,54 +2537,59 @@ { "history": [ { - "id": "095604dd-7271-4d43-99ab-39fafdf6a099", + "id": "0b2347b7-3b85-442d-aa46-e9c5c9ee7802", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "reason": { - "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", - "display": "Bösartige Neubildung: Isthmus uteri", + "id": "c1731d5e-6cca-4f8e-bca6-de233926106e", + "display": "Bösartige Neubildung: Zentraler Drüsenkörper der Brustdrüse", "type": "MTBDiagnosis" }, "intent": { - "code": "K", - "display": "Kurativ", + "code": "P", + "display": "Palliativ", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "N", - "display": "Neoadjuvant", + "code": "S", + "display": "Sonstiges", "system": "dnpm-dip/therapy/category" }, "basedOn": { - "id": "6a91f8db-8cde-4be1-84c6-f0c4fd4a2105", + "id": "1db4d8d9-d6c0-48d1-b135-d040403654f9", "type": "MTBMedicationRecommendation" }, - "recordedOn": "2025-06-18", + "recordedOn": "2025-06-24", "status": { - "code": "completed", - "display": "Abgeschlossen", + "code": "stopped", + "display": "Abgebrochen", "system": "dnpm-dip/therapy/status" }, + "statusReason": { + "code": "progression", + "display": "Progression", + "system": "dnpm-dip/therapy/status-reason" + }, "recommendationFulfillmentStatus": { "code": "partial", "display": "Partiell", "system": "dnpm-dip/therapy/recommendation-fulfillment-status" }, "dosage": { - "code": "over-50%", - "display": ">= 50 %", + "code": "under-50%", + "display": "< 50 %", "system": "dnpm-dip/therapy/dosage-density" }, "period": { - "start": "2009-07-20", - "end": "2010-01-04" + "start": "2025-03-18", + "end": "2025-06-24" }, "medication": [ { - "code": "L01XX79", - "display": "Eflornithin", + "code": "L01XX77", + "display": "Adagrasib", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -2787,19 +2603,19 @@ ], "responses": [ { - "id": "d2d28592-a1bf-414b-a137-c55a2f22aa64", + "id": "70c6b774-ca26-4837-b424-5fc37e9a1548", "patient": { - "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "id": "aca5a971-28be-4089-8128-0036a4fe6f1a", "type": "Patient" }, "therapy": { - "id": "095604dd-7271-4d43-99ab-39fafdf6a099", + "id": "0b2347b7-3b85-442d-aa46-e9c5c9ee7802", "type": "MTBSystemicTherapy" }, - "effectiveDate": "2009-10-19", + "effectiveDate": "2025-06-03", "method": { - "code": "RECIST", - "display": "Nach RECIST-Kriterien", + "code": "RANO", + "display": "Nach RANO-Kriterien", "system": "dnpm-dip/mtb/response/method" }, "value": {