diff --git a/mtb.go b/mtb.go index 6bec79e..13da8bb 100644 --- a/mtb.go +++ b/mtb.go @@ -222,12 +222,12 @@ type StudyReference struct { } type ClaimResponse struct { - Claim Reference `json:"claim"` - ID string `json:"id"` - IssuedOn string `json:"issuedOn"` - Patient Reference `json:"patient"` - Status ClaimResponseStatusCoding `json:"status"` - StatusReason *ClaimResponseStatusReasonCoding `json:"statusReason,omitempty"` + Claim Reference `json:"claim"` + ID string `json:"id"` + IssuedOn string `json:"issuedOn"` + Patient Reference `json:"patient"` + Status *ClaimResponseStatusCoding `json:"status,omitempty"` + StatusReason []ClaimResponseStatusReasonCoding `json:"statusReason,omitempty"` } type ClaimResponseStatusCoding struct { @@ -476,13 +476,11 @@ type TumorMorphology struct { } type IhcReport struct { - BlockIDS []string `json:"blockIds"` - ID string `json:"id"` - IssuedOn string `json:"issuedOn"` - JournalID string `json:"journalId"` - Patient Reference `json:"patient"` - Results IhcReportResults `json:"results"` - Specimen Reference `json:"specimen"` + ID string `json:"id"` + IssuedOn string `json:"issuedOn"` + Patient Reference `json:"patient"` + Results IhcReportResults `json:"results"` + Specimen Reference `json:"specimen"` } type IhcReportResults struct { diff --git a/tests/mv64e-mtb-fake-patient.json b/tests/mv64e-mtb-fake-patient.json index 5895be5..c9fb5b2 100644 --- a/tests/mv64e-mtb-fake-patient.json +++ b/tests/mv64e-mtb-fake-patient.json @@ -1,12 +1,13 @@ { "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "gender": { - "code": "male", - "display": "Männlich", + "code": "female", + "display": "Weiblich", "system": "Gender" }, - "birthDate": "1993-08-01", + "birthDate": "1994-01-04", + "dateOfDeath": "2010-01-04", "healthInsurance": { "type": { "code": "GKV", @@ -24,28 +25,28 @@ "municipalityCode": "12345" }, "age": { - "value": 31, + "value": 16, "unit": "Years" }, "vitalStatus": { - "code": "alive", - "display": "Lebend", + "code": "deceased", + "display": "Verstorben", "system": "dnpm-dip/patient/vital-status" } }, "episodesOfCare": [ { - "id": "dc4d1b2c-7468-4a4a-8fbd-1b0bb645c082", + "id": "4bdf2967-2e9f-4fac-9210-764918dc9e7e", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "period": { - "start": "2024-11-30" + "start": "2024-12-18" }, "diagnoses": [ { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", "type": "MTBDiagnosis" } ] @@ -53,12 +54,12 @@ ], "diagnoses": [ { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, - "recordedOn": "2022-09-01", + "recordedOn": "2006-05-04", "type": { "history": [ { @@ -67,35 +68,35 @@ "display": "Hauptdiagnose", "system": "dnpm-dip/mtb/diagnosis/type" }, - "date": "2022-09-01" + "date": "2006-05-04" } ] }, "code": { - "code": "C57.0", - "display": "Bösartige Neubildung: Tuba uterina [Falloppio]", + "code": "C54.0", + "display": "Bösartige Neubildung: Isthmus uteri", "system": "http://fhir.de/CodeSystem/bfarm/icd-10-gm", "version": "2025" }, "topography": { - "code": "C57.0", - "display": "Eileiter", + "code": "C54.0", + "display": "Isthmus uteri", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "grading": { "history": [ { - "date": "2022-09-01", + "date": "2006-05-04", "codes": [ { - "code": "4", - "display": "4 = undifferenziert", + "code": "H", + "display": "H = high grade (G3 oder G4)", "system": "https://www.basisdatensatz.de/feld/161/grading" }, { - "code": "1", - "display": "Pilocytic astrocytoma", + "code": "3", + "display": "Anaplastic astrocytoma", "system": "dnpm-dip/mtb/who-grading-cns-tumors", "version": "2021" } @@ -106,7 +107,7 @@ "staging": { "history": [ { - "date": "2022-09-01", + "date": "2006-05-04", "method": { "code": "clinical", "display": "Klinisch", @@ -114,11 +115,11 @@ }, "tnmClassification": { "tumor": { - "code": "T1", + "code": "Tx", "system": "UICC" }, "nodes": { - "code": "N3", + "code": "N0", "system": "UICC" }, "metastasis": { @@ -128,8 +129,8 @@ }, "otherClassifications": [ { - "code": "local", - "display": "Lokal", + "code": "metastasized", + "display": "Metastasiert", "system": "dnpm-dip/mtb/diagnosis/kds-tumor-spread" } ] @@ -137,8 +138,8 @@ ] }, "guidelineTreatmentStatus": { - "code": "no-guidelines-available", - "display": "Keine Leitlinien vorhanden", + "code": "non-exhausted", + "display": "Leitlinien nicht ausgeschöpft", "system": "dnpm-dip/mtb/diagnosis/guideline-treatment-status" }, "notes": [ @@ -148,28 +149,28 @@ ], "guidelineTherapies": [ { - "id": "b63bcd3e-1bbb-425d-bd4f-03820036e249", + "id": "63d3a2df-c1c7-40b6-9b4c-796b7f67e098", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "reason": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", - "display": "Bösartige Neubildung: Tuba uterina [Falloppio]", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "display": "Bösartige Neubildung: Isthmus uteri", "type": "MTBDiagnosis" }, - "therapyLine": 8, + "therapyLine": 2, "intent": { - "code": "X", - "display": "Keine Angabe", + "code": "P", + "display": "Palliativ", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "S", - "display": "Sonstiges", + "code": "N", + "display": "Neoadjuvant", "system": "dnpm-dip/therapy/category" }, - "recordedOn": "2025-05-30", + "recordedOn": "2025-06-18", "status": { "code": "stopped", "display": "Abgebrochen", @@ -181,13 +182,13 @@ "system": "dnpm-dip/therapy/status-reason" }, "period": { - "start": "2024-05-30", - "end": "2024-08-22" + "start": "2023-10-18", + "end": "2024-06-19" }, "medication": [ { - "code": "L01XX57", - "display": "Plitidepsin", + "code": "L01EX28", + "display": "Repotrectinib", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -197,28 +198,28 @@ ] }, { - "id": "d7de61c1-a5cc-429b-9c6f-e47765828f90", + "id": "c8b0432c-f190-4dfe-a22a-0d00969ccdce", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "reason": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", - "display": "Bösartige Neubildung: Tuba uterina [Falloppio]", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "display": "Bösartige Neubildung: Isthmus uteri", "type": "MTBDiagnosis" }, - "therapyLine": 5, + "therapyLine": 2, "intent": { - "code": "P", - "display": "Palliativ", + "code": "S", + "display": "Sonstiges", "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "S", - "display": "Sonstiges", + "code": "N", + "display": "Neoadjuvant", "system": "dnpm-dip/therapy/category" }, - "recordedOn": "2025-05-30", + "recordedOn": "2025-06-18", "status": { "code": "stopped", "display": "Abgebrochen", @@ -230,13 +231,13 @@ "system": "dnpm-dip/therapy/status-reason" }, "period": { - "start": "2024-02-29", - "end": "2024-10-03" + "start": "2023-10-18", + "end": "2024-05-01" }, "medication": [ { - "code": "L01XX29", - "display": "Denileukindiftitox", + "code": "L01XX86", + "display": "Calaspargase pegol", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -248,20 +249,20 @@ ], "guidelineProcedures": [ { - "id": "960c989f-12f0-4592-96a8-fcb55938cd38", + "id": "380e2338-5cab-45f3-83f1-7e655b560c7c", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "reason": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", - "display": "Bösartige Neubildung: Tuba uterina [Falloppio]", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "display": "Bösartige Neubildung: Isthmus uteri", "type": "MTBDiagnosis" }, "therapyLine": 3, "intent": { - "code": "X", - "display": "Keine Angabe", + "code": "K", + "display": "Kurativ", "system": "dnpm-dip/therapy/intent" }, "code": { @@ -270,18 +271,58 @@ "system": "dnpm-dip/mtb/procedure/type" }, "status": { - "code": "on-going", - "display": "Laufend", + "code": "completed", + "display": "Abgeschlossen", "system": "dnpm-dip/therapy/status" }, "statusReason": { - "code": "payment-pending", - "display": "Kostenübernahme noch ausstehend", + "code": "chronic-remission", + "display": "Anhaltende Remission", "system": "dnpm-dip/therapy/status-reason" }, - "recordedOn": "2025-05-30", + "recordedOn": "2025-06-18", "period": { - "start": "2024-11-30" + "start": "2024-12-18" + }, + "notes": [ + "Notes on the therapeutic procedure..." + ] + }, + { + "id": "52a639e2-a857-4d36-b115-9537542207f8", + "patient": { + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "type": "Patient" + }, + "reason": { + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "display": "Bösartige Neubildung: Isthmus uteri", + "type": "MTBDiagnosis" + }, + "therapyLine": 5, + "intent": { + "code": "P", + "display": "Palliativ", + "system": "dnpm-dip/therapy/intent" + }, + "code": { + "code": "surgery", + "display": "OP", + "system": "dnpm-dip/mtb/procedure/type" + }, + "status": { + "code": "stopped", + "display": "Abgebrochen", + "system": "dnpm-dip/therapy/status" + }, + "statusReason": { + "code": "patient-refusal", + "display": "Therapie durch Patient abgelehnt", + "system": "dnpm-dip/therapy/status-reason" + }, + "recordedOn": "2025-06-18", + "period": { + "start": "2024-12-18" }, "notes": [ "Notes on the therapeutic procedure..." @@ -290,12 +331,12 @@ ], "performanceStatus": [ { - "id": "2d5108a3-600c-4153-8600-0427ad00d8a9", + "id": "fa501ef1-8861-495c-b267-0ebf25eab69d", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, - "effectiveDate": "2025-05-30", + "effectiveDate": "2025-06-18", "value": { "code": "5", "display": "ECOG 5", @@ -305,30 +346,30 @@ ], "specimens": [ { - "id": "c59253e3-3c11-40bd-bc35-7c089f734862", + "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "diagnosis": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", "type": "MTBDiagnosis" }, "type": { - "code": "unknown", - "display": "Unbekannt", + "code": "fresh-tissue", + "display": "Frischgewebe", "system": "dnpm-dip/mtb/tumor-specimen/type" }, "collection": { - "date": "2025-05-30", + "date": "2025-06-18", "method": { - "code": "unknown", - "display": "Unbekannt", + "code": "biopsy", + "display": "Biopsie", "system": "dnpm-dip/mtb/tumor-specimen/collection/method" }, "localization": { - "code": "primary-tumor", - "display": "Primärtumor", + "code": "local-recurrence", + "display": "Lokalrezidiv", "system": "dnpm-dip/mtb/tumor-specimen/collection/localization" } } @@ -336,9 +377,9 @@ ], "priorDiagnosticReports": [ { - "id": "c02f0997-c43f-4da0-819e-d7ae7370d78d", + "id": "c628b8ee-cb29-48e7-961f-2808ca4005ed", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "performer": { @@ -346,14 +387,14 @@ "display": "Molekular-Pathologie UKx", "type": "Institute" }, - "issuedOn": "2025-05-30", + "issuedOn": "2025-06-18", "specimen": { - "id": "c59253e3-3c11-40bd-bc35-7c089f734862", + "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", "type": "TumorSpecimen" }, "type": { - "code": "karyotyping", - "display": "Karyotyping", + "code": "gene-panel", + "display": "Genpanel", "system": "dnpm-dip/mtb/molecular-diagnostics/type" }, "results": [ @@ -363,43 +404,43 @@ ], "histologyReports": [ { - "id": "791de8a5-b766-42d5-9454-12fbfe25ad92", + "id": "818d2577-989b-46dc-bd9a-4d5416b4dd11", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "specimen": { - "id": "c59253e3-3c11-40bd-bc35-7c089f734862", + "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", "type": "TumorSpecimen" }, - "issuedOn": "2025-05-30", + "issuedOn": "2025-06-18", "results": { "tumorMorphology": { - "id": "699db4c1-74a1-4c0f-bc20-275f85abfd20", + "id": "fd271a56-9287-40a2-ac18-f33874c91170", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "specimen": { - "id": "c59253e3-3c11-40bd-bc35-7c089f734862", + "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", "type": "TumorSpecimen" }, "value": { - "code": "8891/0", - "display": "Epitheloides Leiomyom", + "code": "9725/1", + "display": "Hydroa-vacciniform-lymphoproliferative Erkrankung", "system": "urn:oid:2.16.840.1.113883.6.43.1", "version": "Zweite Revision" }, "note": "Notes..." }, "tumorCellContent": { - "id": "5c408779-8f1c-4c44-a3f1-0bee32a0b7f1", + "id": "856a7ed6-fc28-4beb-a0bf-c96895c1c2bb", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "specimen": { - "id": "c59253e3-3c11-40bd-bc35-7c089f734862", + "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", "type": "TumorSpecimen" }, "method": { @@ -407,94 +448,34 @@ "display": "Histologisch", "system": "dnpm-dip/mtb/tumor-cell-content/method" }, - "value": 0.022777185931090127 + "value": 0.7691964184191502 } } } ], "ihcReports": [ { - "id": "d913c59b-7788-4931-a24c-5a71995ee77b", + "id": "cfded8da-7ca9-4e54-adfc-e3a723a2aaec", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "specimen": { - "id": "c59253e3-3c11-40bd-bc35-7c089f734862", + "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", "type": "TumorSpecimen" }, - "issuedOn": "2025-05-30", - "journalId": "7f39e2f3-6b0f-486d-b2d2-a1c8c4ec0493", - "blockIds": [ - "a91d53a8-7949-4233-b710-1f1b456ff8c7" - ], + "issuedOn": "2025-06-18", "results": { "proteinExpression": [ { - "id": "60538b11-9da7-4248-a878-00dbfe31cf37", + "id": "71b2cbc9-c250-4fdf-95f8-11ef68c7119c", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "protein": { - "code": "HGNC:34", - "display": "ABCA4", - "system": "https://www.genenames.org/" - }, - "value": { - "code": "2+", - "display": "2+", - "system": "dnpm-dip/mtb/ihc/protein-expression/result" - }, - "tpsScore": 15, - "icScore": { - "code": "3", - "display": ">= 10%", - "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" - }, - "tcScore": { - "code": "5", - "display": ">= 50%", - "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" - } - }, - { - "id": "32a8c01c-4bd7-4ae9-8835-6ba747fe1991", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "protein": { - "code": "HGNC:886", - "display": "ATRX", - "system": "https://www.genenames.org/" - }, - "value": { - "code": "not-exp", - "display": "Nicht exprimiert", - "system": "dnpm-dip/mtb/ihc/protein-expression/result" - }, - "tpsScore": 33, - "icScore": { - "code": "2", - "display": ">= 5%", - "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" - }, - "tcScore": { - "code": "5", - "display": ">= 50%", - "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" - } - }, - { - "id": "edd1cb04-8c1a-49f7-bb88-36ee576ade21", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "protein": { - "code": "HGNC:886", - "display": "ATRX", + "code": "HGNC:3236", + "display": "EGFR", "system": "https://www.genenames.org/" }, "value": { @@ -502,7 +483,63 @@ "display": "3+", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 95, + "tpsScore": 45, + "icScore": { + "code": "3", + "display": ">= 10%", + "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" + }, + "tcScore": { + "code": "4", + "display": ">= 25%", + "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" + } + }, + { + "id": "6137eab8-f33b-4f98-a9b3-78589815cb1b", + "patient": { + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "type": "Patient" + }, + "protein": { + "code": "HGNC:76", + "display": "ABL1", + "system": "https://www.genenames.org/" + }, + "value": { + "code": "unknown", + "display": "untersucht, kein Ergebnis", + "system": "dnpm-dip/mtb/ihc/protein-expression/result" + }, + "tpsScore": 82, + "icScore": { + "code": "1", + "display": ">= 1%", + "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" + }, + "tcScore": { + "code": "4", + "display": ">= 25%", + "system": "dnpm-dip/mtb/ihc/protein-expression/tc-score" + } + }, + { + "id": "13725397-cb4a-4c66-a616-925c692e7a5b", + "patient": { + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "type": "Patient" + }, + "protein": { + "code": "HGNC:391", + "display": "AKT1", + "system": "https://www.genenames.org/" + }, + "value": { + "code": "unknown", + "display": "untersucht, kein Ergebnis", + "system": "dnpm-dip/mtb/ihc/protein-expression/result" + }, + "tpsScore": 10, "icScore": { "code": "2", "display": ">= 5%", @@ -515,14 +552,14 @@ } }, { - "id": "8e7f8610-2bab-4baa-9567-98a0c71eead4", + "id": "3eeb2b9d-d482-4e53-bc74-facb50bd9ea3", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "protein": { - "code": "HGNC:33", - "display": "ABCA3", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, "value": { @@ -530,10 +567,10 @@ "display": "Nicht exprimiert", "system": "dnpm-dip/mtb/ihc/protein-expression/result" }, - "tpsScore": 81, + "tpsScore": 10, "icScore": { - "code": "3", - "display": ">= 10%", + "code": "1", + "display": ">= 1%", "system": "dnpm-dip/mtb/ihc/protein-expression/ic-score" }, "tcScore": { @@ -543,30 +580,86 @@ } }, { - "id": "845b905d-eef9-4a2c-9aff-cde382933968", + "id": 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"https://www.genenames.org/" }, { @@ -1408,36 +1774,36 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:3942", - "display": "MTOR", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, { - "code": "HGNC:3236", - "display": "EGFR", + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:3689", + "display": "FGFR2", "system": "https://www.genenames.org/" } ], "reportedFocality": "partial q-arm", "type": { - "code": "high-level-gain", - "display": "High-level-gain", + "code": "loss", + "display": "Loss", "system": "dnpm-dip/mtb/ngs-report/cnv/type" }, "copyNumberNeutralLoH": [ { - "code": "HGNC:11998", - "display": "TP53", + "code": "HGNC:33", + "display": "ABCA3", "system": "https://www.genenames.org/" }, { - "code": "HGNC:6973", - "display": "MDM2", - "system": "https://www.genenames.org/" - }, - { - "code": "HGNC:1753", - "display": "CDH13", + "code": "HGNC:25662", + "display": "AAGAB", "system": "https://www.genenames.org/" }, { @@ -1451,8 +1817,18 @@ "system": "https://www.genenames.org/" }, { - "code": "HGNC:21597", - "display": "ACAD10", + "code": "HGNC:21298", + "display": "AACS", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:18615", + "display": "BRAFP1", + "system": "https://www.genenames.org/" + }, + { + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" } ] @@ -1460,42 +1836,75 @@ ], "dnaFusions": [ { - "id": "1901fef1-f341-49cd-80b3-80af8f6f7bea", + "id": "0cbe5df0-8c5e-4352-ae80-58b18bc99e03", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "localization": [ { - "code": "splicing-region", - "display": "splicing region", + "code": "regulatory-region", + "display": "Regulatory region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - "chromosome": "chr9", + "chromosome": "chr12", "gene": { - "code": "HGNC:21597", - "display": "ACAD10", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" }, - "position": 968 + "position": 694 }, "fusionPartner3prime": { - "chromosome": "chrX", + "chromosome": "chr4", "gene": { - "code": "HGNC:6407", - "display": "KRAS", + "code": "HGNC:1097", + "display": "BRAF", "system": "https://www.genenames.org/" }, - "position": 61 + "position": 125 }, - "reportedNumReads": 7 + "reportedNumReads": 6 }, { - "id": "12ca0894-8fe6-4243-aed7-d630df490cac", + "id": "a17f336a-0ea4-4bb7-8e46-8fd3ea8c400e", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", + "type": "Patient" + }, + "localization": [ + { + "code": "intergenic", + "display": "Intergenic", + "system": "dnpm-dip/variant/localization" + } + ], + "fusionPartner5prime": { + "chromosome": "chr14", + "gene": { + "code": "HGNC:1753", + "display": "CDH13", + "system": "https://www.genenames.org/" + }, + "position": 519 + }, + "fusionPartner3prime": { + "chromosome": "chr4", + "gene": { + "code": "HGNC:11998", + "display": "TP53", + "system": "https://www.genenames.org/" + }, + "position": 431 + }, + "reportedNumReads": 6 + }, + { + "id": "e0cb222c-e12d-492d-8d09-bfcebb2dae96", + "patient": { + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "localization": [ @@ -1506,62 +1915,62 @@ } ], "fusionPartner5prime": { - "chromosome": "chr20", + "chromosome": "chrX", "gene": { - "code": "HGNC:18615", - "display": "BRAFP1", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" }, - "position": 462 + "position": 573 }, "fusionPartner3prime": { - "chromosome": "chr3", + "chromosome": "chr16", "gene": { "code": "HGNC:3942", "display": "MTOR", "system": "https://www.genenames.org/" }, - "position": 984 + "position": 590 }, - "reportedNumReads": 5 + "reportedNumReads": 7 }, { - "id": "17335f8f-1ac4-43a7-9fdf-5574d8390bf5", + "id": "7574a407-064d-43f7-b01a-3ee314de17ab", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "localization": [ { - "code": "intronic", - "display": "Intronic", + "code": "splicing-region", + "display": "splicing region", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { "chromosome": "chr21", "gene": { - "code": "HGNC:1100", - "display": "BRCA1", + "code": "HGNC:3690", + "display": "FGFR3", "system": "https://www.genenames.org/" }, - "position": 930 + "position": 370 }, "fusionPartner3prime": { - "chromosome": "chr14", + "chromosome": "chr8", "gene": { - "code": "HGNC:76", - "display": "ABL1", + "code": "HGNC:6407", + "display": "KRAS", "system": "https://www.genenames.org/" }, - "position": 896 + "position": 376 }, - "reportedNumReads": 7 + "reportedNumReads": 9 }, { - "id": "a6acd3bb-127b-44f6-8331-dc4b2488ed38", + "id": "cf273d27-7296-430a-b333-8533401e33d0", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "localization": [ @@ -1572,62 +1981,29 @@ } ], "fusionPartner5prime": { - "chromosome": "chr8", + "chromosome": "chr22", "gene": { "code": "HGNC:1097", "display": "BRAF", "system": "https://www.genenames.org/" }, - "position": 460 + "position": 374 }, "fusionPartner3prime": { - "chromosome": "chr19", + "chromosome": "chr16", "gene": { - "code": "HGNC:3236", - "display": "EGFR", + "code": "HGNC:11998", + "display": "TP53", "system": "https://www.genenames.org/" }, - "position": 577 - }, - "reportedNumReads": 9 - }, - { - "id": "4705fb0d-d429-47d6-8191-c07d06d16c7a", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "localization": [ - { - "code": "regulatory-region", - "display": "Regulatory region", - "system": "dnpm-dip/variant/localization" - } - ], - "fusionPartner5prime": { - "chromosome": "chr19", - "gene": { - "code": "HGNC:25662", - "display": "AAGAB", - "system": "https://www.genenames.org/" - }, - "position": 270 - }, - "fusionPartner3prime": { - "chromosome": "chr5", - "gene": { - "code": "HGNC:21298", - "display": "AACS", - "system": "https://www.genenames.org/" - }, - "position": 124 + "position": 866 }, "reportedNumReads": 3 }, { - "id": "9df78e1b-5126-4e72-9d3b-09ddc0fc4d0c", + "id": "ac3ea44e-b378-4ddc-bf69-d4de67714377", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "localization": [ @@ -1638,152 +2014,69 @@ } ], "fusionPartner5prime": { - "chromosome": "chr9", + "chromosome": "chr20", "gene": { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:9967", + "display": "RET", "system": "https://www.genenames.org/" }, - "position": 658 + "position": 388 }, "fusionPartner3prime": { - "chromosome": "chr1", + "chromosome": "chr22", "gene": { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:21298", + "display": "AACS", "system": "https://www.genenames.org/" }, - "position": 805 + "position": 447 }, - "reportedNumReads": 7 + "reportedNumReads": 3 }, { - "id": "60c7636c-7207-4dbd-bf1f-35fba21137b5", + "id": "0d9ff226-62b1-4402-b4c2-ed763a008e85", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "localization": [ { - "code": "coding-region", - "display": "Coding region", + "code": "intronic", + "display": "Intronic", "system": "dnpm-dip/variant/localization" } ], "fusionPartner5prime": { - "chromosome": "chr11", - "gene": { - "code": "HGNC:3689", - "display": "FGFR2", - "system": "https://www.genenames.org/" - }, - "position": 146 - }, - "fusionPartner3prime": { - "chromosome": "chr13", + "chromosome": "chr8", "gene": { "code": "HGNC:886", "display": "ATRX", "system": "https://www.genenames.org/" }, - "position": 521 - }, - "reportedNumReads": 5 - }, - { - "id": "ade9cd16-516a-4725-b803-51402b8913b2", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "localization": [ - { - "code": "intergenic", - "display": "Intergenic", - "system": "dnpm-dip/variant/localization" - } - ], - "fusionPartner5prime": { - "chromosome": "chr13", - "gene": { - "code": "HGNC:3689", - "display": "FGFR2", - "system": "https://www.genenames.org/" - }, - "position": 555 + "position": 741 }, "fusionPartner3prime": { - "chromosome": "chrY", + "chromosome": "chr7", "gene": { - "code": "HGNC:3690", - "display": "FGFR3", + "code": "HGNC:34", + "display": "ABCA4", "system": "https://www.genenames.org/" }, - "position": 510 + "position": 247 }, - "reportedNumReads": 9 + "reportedNumReads": 3 } ], "rnaFusions": [ { - "id": "1da6ea65-074a-4850-b2a5-d6c014ba34ec", + "id": "c449c682-a9b3-4670-8112-71e1d2887fdc", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "externalIds": [ { - "value": 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"SO", + "display": "Sonstiges", "system": "dnpm-dip/mtb/recommendation/procedure/category" }, "supportingVariants": [ { "variant": { - "id": "7748dd2f-e547-4412-996b-c8116040a5d4", + "id": "a17f336a-0ea4-4bb7-8e46-8fd3ea8c400e", "type": "Variant" }, "gene": { - "code": "HGNC:25829", - "display": "ABRAXAS1", + "code": "HGNC:1753", + "display": "CDH13", "system": "https://www.genenames.org/" } } @@ -2259,21 +2582,21 @@ ], "studyEnrollmentRecommendations": [ { - "id": "3d4c243c-2908-46b7-9faf-d795fd883ac0", + "id": "9e830774-b888-4cb2-8883-29bb6513c4a9", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "reason": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", - "display": "Bösartige Neubildung: Tuba uterina [Falloppio]", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "display": "Bösartige Neubildung: Isthmus uteri", "type": "MTBDiagnosis" }, - "issuedOn": "2025-05-30", + "issuedOn": "2025-06-18", "levelOfEvidence": { "grading": { - "code": "m2A", - "display": "m2A", + "code": "undefined", + "display": "Nicht definiert", "system": "dnpm-dip/mtb/level-of-evidence/grading" }, "addendums": [ @@ -2285,33 +2608,33 @@ ], "publications": [ { - "id": "482370142", + "id": "1570997794", "system": "https://pubmed.ncbi.nlm.nih.gov", "type": "Publication" } ] }, "priority": { - "code": "4", - "display": "4", + "code": "3", + "display": "3", "system": "dnpm-dip/recommendation/priority" }, "study": [ { - "id": "8547-845744-34-56", - "system": "Eudra-CT", + "id": "DRKS00003728", + "system": "DRKS", "type": "Study" } ], "supportingVariants": [ { "variant": { - "id": "4705fb0d-d429-47d6-8191-c07d06d16c7a", + "id": "0cbe5df0-8c5e-4352-ae80-58b18bc99e03", "type": "Variant" }, "gene": { - "code": "HGNC:25662", - "display": "AAGAB", + "code": "HGNC:886", + "display": "ATRX", "system": "https://www.genenames.org/" } } @@ -2320,30 +2643,30 @@ ], "histologyReevaluationRequests": [ { - "id": "a641f201-fa1e-4650-8fba-adf3665040ed", + "id": "4409db9f-6560-41e8-a7fd-4a5a398d917e", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "specimen": { - "id": "c59253e3-3c11-40bd-bc35-7c089f734862", + "id": "ca83408d-7ad5-4998-ab2b-a8f705cc929d", "type": "TumorSpecimen" }, - "issuedOn": "2025-05-30" + "issuedOn": "2025-06-18" } ], "rebiopsyRequests": [ { - "id": "2501cd78-c360-40c1-9ced-455fa7172191", + "id": "692b1fec-1ed2-4c70-a6d1-d1d1fdec160b", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "tumorEntity": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", "type": "MTBDiagnosis" }, - "issuedOn": "2025-05-30" + "issuedOn": "2025-06-18" } ], "notes": [ @@ -2353,43 +2676,26 @@ ], "followUps": [ { - "date": "2025-02-07", + "date": "2009-10-19", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, - "lastContactDate": "2025-02-07" + "lastContactDate": "2009-10-19" } ], "claims": [ { - "id": "4aa57f09-d47a-4916-852e-c79175a0eca7", + "id": "5f9a50b7-582f-404f-b50c-92077e19daba", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "recommendation": { - "id": "8c9e7e7f-daea-4b7b-ad72-6ef6be070f95", + "id": "6a91f8db-8cde-4be1-84c6-f0c4fd4a2105", "type": "MTBMedicationRecommendation" }, - "issuedOn": "2025-05-30", - "stage": { - "code": "revocation", - "display": "Widerspruch", - "system": "dnpm-dip/mtb/claim/stage" - } - }, - { - "id": "fa9b668c-c39d-42a9-bdb2-410bc3f4a361", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "recommendation": { - "id": "5adb8293-f9d1-4e65-bdcf-9d4803bd9d1c", - "type": "MTBMedicationRecommendation" - }, - "issuedOn": "2025-05-30", + "issuedOn": "2025-06-18", "stage": { "code": "initial-claim", "display": "Erstantrag", @@ -2399,33 +2705,16 @@ ], "claimResponses": [ { - "id": "db18a72a-293e-4f2d-bfe5-273776f8286b", + "id": "be291eca-2333-41e1-bcd2-e845212049ba", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "claim": { - "id": "4aa57f09-d47a-4916-852e-c79175a0eca7", + "id": "5f9a50b7-582f-404f-b50c-92077e19daba", "type": "Claim" }, - "issuedOn": "2025-05-30", - "status": { - "code": "accepted", - "display": "Angenommen", - "system": "dnpm-dip/mtb/claim-response/status" - } - }, - { - "id": "ff5f495e-20c6-4c18-b150-4799343049c4", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "claim": { - "id": "fa9b668c-c39d-42a9-bdb2-410bc3f4a361", - "type": "Claim" - }, - "issuedOn": "2025-05-30", + "issuedOn": "2025-06-18", "status": { "code": "accepted", "display": "Angenommen", @@ -2437,75 +2726,14 @@ { "history": [ { - "id": "bc0b340d-17ea-4598-ad69-38d309e47182", + "id": "095604dd-7271-4d43-99ab-39fafdf6a099", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "reason": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", - "display": "Bösartige Neubildung: Tuba uterina [Falloppio]", - "type": "MTBDiagnosis" - }, - "intent": { - "code": "X", - "display": "Keine Angabe", - "system": "dnpm-dip/therapy/intent" - }, - "category": { - "code": "N", - "display": "Neoadjuvant", - "system": "dnpm-dip/therapy/category" - }, - "basedOn": { - "id": "8c9e7e7f-daea-4b7b-ad72-6ef6be070f95", - "type": "MTBMedicationRecommendation" - }, - "recordedOn": "2025-05-30", - "status": { - "code": "on-going", - "display": "Laufend", - "system": "dnpm-dip/therapy/status" - }, - "recommendationFulfillmentStatus": { - "code": "partial", - "display": "Partiell", - "system": "dnpm-dip/therapy/recommendation-fulfillment-status" - }, - "dosage": { - "code": "under-50%", - "display": "< 50 %", - "system": "dnpm-dip/therapy/dosage-density" - }, - "period": { - "start": "2024-11-08", - "end": "2025-05-30" - }, - "medication": [ - { - "code": "L01EX01", - "display": "Sunitinib", - "system": "http://fhir.de/CodeSystem/bfarm/atc", - "version": "2025" - } - ], - "notes": [ - "Notes on the therapy..." - ] - } - ] - }, - { - "history": [ - { - "id": "e3d4b435-0531-4d75-827c-0da914f054dd", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "reason": { - "id": "53155bb3-39f8-4cd9-aa9b-1675165bfdb8", - "display": "Bösartige Neubildung: Tuba uterina [Falloppio]", + "id": "fd3a3a67-bfb6-4101-8516-d6f34e779de4", + "display": "Bösartige Neubildung: Isthmus uteri", "type": "MTBDiagnosis" }, "intent": { @@ -2514,23 +2742,23 @@ "system": "dnpm-dip/therapy/intent" }, "category": { - "code": "A", - "display": "Adjuvant", + "code": "N", + "display": "Neoadjuvant", "system": "dnpm-dip/therapy/category" }, "basedOn": { - "id": "5adb8293-f9d1-4e65-bdcf-9d4803bd9d1c", + "id": "6a91f8db-8cde-4be1-84c6-f0c4fd4a2105", "type": "MTBMedicationRecommendation" }, - "recordedOn": "2025-05-30", + "recordedOn": "2025-06-18", "status": { "code": "completed", "display": "Abgeschlossen", "system": "dnpm-dip/therapy/status" }, "recommendationFulfillmentStatus": { - "code": "complete", - "display": "Komplett", + "code": "partial", + "display": "Partiell", "system": "dnpm-dip/therapy/recommendation-fulfillment-status" }, "dosage": { @@ -2539,13 +2767,13 @@ "system": "dnpm-dip/therapy/dosage-density" }, "period": { - "start": "2024-10-25", - "end": "2025-05-30" + "start": "2009-07-20", + "end": "2010-01-04" }, "medication": [ { - "code": "L01FX01", - "display": "Edrecolomab", + "code": "L01XX79", + "display": "Eflornithin", "system": "http://fhir.de/CodeSystem/bfarm/atc", "version": "2025" } @@ -2559,38 +2787,16 @@ ], "responses": [ { - "id": "1bcd9695-739f-451b-a403-7def6fa43614", + "id": "d2d28592-a1bf-414b-a137-c55a2f22aa64", "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", + "id": "47d1425b-a7ab-43d3-af77-623b3eaf18e0", "type": "Patient" }, "therapy": { - "id": "bc0b340d-17ea-4598-ad69-38d309e47182", + "id": "095604dd-7271-4d43-99ab-39fafdf6a099", "type": "MTBSystemicTherapy" }, - "effectiveDate": "2025-02-07", - "method": { - "code": "RANO", - "display": "Nach RANO-Kriterien", - "system": "dnpm-dip/mtb/response/method" - }, - "value": { - "code": "PR", - "display": "Partial Response", - "system": "RECIST" - } - }, - { - "id": "89f6c606-0ec6-4b1e-a316-56a16eb52ea2", - "patient": { - "id": "e14bf9b6-7982-4933-a648-cfdea6484f1c", - "type": "Patient" - }, - "therapy": { - "id": "e3d4b435-0531-4d75-827c-0da914f054dd", - "type": "MTBSystemicTherapy" - }, - "effectiveDate": "2024-12-27", + "effectiveDate": "2009-10-19", "method": { "code": "RECIST", "display": "Nach RECIST-Kriterien",